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　　報(bào)告題目：Statistical genetics in and out of quasi-linkage equilibrium

　　報(bào)告人：Erik Aurell教授

　　報(bào)告人單位：瑞典皇家理工大學(xué)

　　報(bào)告時(shí)間：2023年8月14日15:30-16:30

　　報(bào)告地點(diǎn)：教2-314會(huì)議室

　　報(bào)告內(nèi)容：

　　This talk is about statistical genetics, an interdisciplinary topic between statisticaphysics and population biology. The focus is on the phase of quasi-linkage equilibrium(OLE). Our goals here are to clarify under which conditions the OLE phase can beexpected to hold in population biology and how the stability of the OlE phase is lostThe OLE state.which has many similaritiesthermal equilibrium state intoastatistical mechanics, was discovered by Kimura for a two-locus two-allele model. andwas extended and generalized to the global genome scale by Nether and Shraiman(2011). What we will refer to as the Kimura-Neher-Shraiman theory describes apopulation evolving due to the mutations. recombination, natural selection andpossibly genetic drift.A OLE phase exists at suffciently high recombination rate andor mutation rates with respect to selection strength.We showhowin OLEitispossible to infer the epistatic parameters of the fitness function from the knowledge ofthe (dynamical) distribution of genotypes in a population. We further consider thebreakdown of the OLE regime for high enough selection strength. We review recentresults for the selection-mutation and selection-recombination dynamics. Finally. weidentify and characterize a new phase which we call the non-random coexistencewhere variability persists in the population without either fixating or disappearing.

　　報(bào)告人簡(jiǎn)介：

　　Erik Aurell教授，1989年博士畢業(yè)于瑞典哥德堡大學(xué)理論物理專業(yè)，隨后分別在法國(guó)巴黎理論物理研究所、美國(guó)康內(nèi)爾大學(xué)、瑞典斯德哥爾摩大學(xué)、北歐物理研究所等機(jī)構(gòu)擔(dān)任研究員，從事非線性科學(xué)、隨機(jī)組合優(yōu)化、非平衡統(tǒng)計(jì)物理、生物信息學(xué)等諸多方向的研究。2003年起，擔(dān)任瑞典皇家理工大學(xué)生物物理系Chair教授，同時(shí)任芬蘭杰出教授(瑞典皇家理工大學(xué)-芬蘭阿爾托大學(xué)聯(lián)合教授)，中國(guó)科學(xué)院客座教授等。目前，Aurell教授發(fā)表專業(yè)論文近300篇，其中多篇發(fā)表于PRL、PNAS等具有重要國(guó)際影響的學(xué)術(shù)期刊上，是國(guó)際統(tǒng)計(jì)物理學(xué)界的知名學(xué)者。近年來(lái)，Aurell教授發(fā)展了統(tǒng)計(jì)物理反問(wèn)題的相關(guān)研究方法和理論，并成功應(yīng)用于基因序列共演化等實(shí)際體系，取得了很有意義的成果。